What is the function of a centromere in a chromosome?

Prepare for the Canadian National Institute of Health Entrance Exam. Study using flashcards and multiple-choice questions, each with hints and explanations. Ace your exam and advance in your academic journey at the CNIH!

The function of a centromere in a chromosome is primarily to attach identical chromatids. The centromere is a specialized region of the chromosome that plays a crucial role during cell division, specifically during the processes of mitosis and meiosis. When a cell prepares to divide, the chromosomes are duplicated, resulting in two identical sister chromatids for each chromosome.

The centromere holds these sister chromatids together until they are ready to separate. During cell division, the spindle fibers attach to the centromere through a protein complex known as the kinetochore. This attachment is essential for the accurate segregation of the chromatids into the daughter cells. If the chromatids were not properly joined by the centromere, they could be unevenly distributed, leading to cells with the incorrect number of chromosomes, which can have serious implications for the organism.

The other choices describe functions that are not aligned with the specific role of the centromere. For example, storing genetic information pertains to the overall structure of DNA within the chromosome, while initiating DNA replication is a function of other proteins and regions in the genome, not the centromere. Lastly, forming the spindle apparatus involves different cellular structures and components entirely rather than the centromere itself.

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